Tuesday, 7 November 2017

1,2-Benzisothiazol-3(2H)-one

Listing description

Synonym: BENZISOTHIAZOLINONE (BIT)
CAS NUMBER 2634-33-5
EMPIRICAL FORMULA(HILL NOTATION)C7H5NOS
MOLECULAR WEIGHT 151.19
EC NUMBER 220-120-9
MDL NUMBER MFD00127753
PUBCHEM SUBSTANCE ID 24879952

Properties

Related Categories
InChI Key  
DMSMPAJRVJJAGA-UHFFFAOYSA-N
assay  
97%
mp  
154-158 °C(lit.)

Description

Packaging

5, 25 g in glass bottle

General description

1,2-Benzisothiazol-3(2H)-one can be synthesized by reacting 2-mercaptobenzoic acid with diphenyl phosphoryl azide.[1]

Benzisothiazolinone (BIT) is a widely used biocide and belongs to the group of isothiazolinones.
Detailed description

Usage

Benzisothiazolinone has a microbicide and a fungicide mode of action. It is widely used as a preservative, for example in:
·         emulsion paintscaulksvarnishesadhesives, inks, and photographic processing solutions
·         home cleaning and car care products; laundry detergents, stain removers and fabric softeners;
·         industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
·         agriculture in pesticide formulations
·         gas and oil drilling in muds and packer fluids preservation.[2]:iv
In paints, it is commonly used alone or as a mixture with methylisothiazolinone. Typical concentrations in products are 200–400 ppmdepending on the application area and the combination with other biocides. According to a study in Switzerland, 19% of the paints, varnishes and coatings contained BIT in 2000. The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%.[3]A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.
PRICE
$23819.97/KG OR $10827.25/IB

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Sunday, 5 November 2017

ACETONE OR PROPANONE [(CH3)2CO]

Listing description

ACS reagent,>99.5%

CAS number 67-64-1

Linear formular CH3COCH3

Molecular weight 58.08

Beilstein registry number 635680

EC NUMBER 200-662-2

MDL number MFCD00008765

pubChem substance ID 329751579

eCl@ss 39021201

Related Categories
More...
grade  
ACS reagent
vapor density  
2 (vs air)
vapor pressure  
184 mmHg ( 20 °C)
InChI Key  
CSCPPACGZOOCGX-UHFFFAOYSA-N
assay  
≥99.5%
form  
liquid (clear)
shelf life  
Recommended retest period - 2 years

 

 

Acetone (systematically named propanone) is the organic compound with the formula (CH3)2CO.[12] It is a colorless, volatile, flammable liquid, and is the simplest ketone.
Acetone is miscible with water and serves as an important solvent in its own right, typically for cleaning purposes in the laboratory. About 6.7 million tonnes were produced worldwide in 2010, mainly for use as a solvent and production of methyl methacrylate and bisphenol A.[13][14] It is a common building block in organic chemistry. Familiar household uses of acetone are as the active ingredient in nail polish remover, and as paint thinner.

Detailed description
Acetone is produced and disposed of in the human body through normal metabolic processes. It is normally present in blood and urine. People with diabetes produce it in larger amounts. Reproductive toxicity tests show that it has low potential to cause reproductive problems. Pregnant women, nursing mothers and children have higher levels of acetone.[15] Ketogenic diets that increase acetone in the body are used to counter epileptic attacks in infants and children who suffer from recalcitrant refractory epilepsy.

Uses[edit]

About a third of the world's acetone is used as a solvent, and a quarter is consumed as acetone cyanohydrin, a precursor to methyl methacrylate.[13]

Solvent[edit]

Acetone is a good solvent for many plastics and some synthetic fibers. It is used for thinning polyester resin, cleaning tools used with it, and dissolving two-part epoxies and superglue before they harden. It is used as one of the volatile components of some paints and varnishes. As a heavy-duty degreaser, it is useful in the preparation of metal prior to painting. It is also useful for high reliability soldering applications to remove rosin flux after soldering is complete; this helps to prevent the rusty bolt effect.
Acetone is used as a solvent by the pharmaceutical industry and as a denaturant in denatured alcohol. Acetone is also present as an excipient in some pharmaceutical drugs.
Although itself flammable, acetone is used extensively as a solvent for the safe transportation and storage of acetylene, which cannot be safely pressurized as a pure compound. Vessels containing a porous material are first filled with acetone followed by acetylene, which dissolves into the acetone. One liter of acetone can dissolve around 250 liters of acetylene at a pressure of 10 bar.

Chemical intermediate

Acetone is used to synthesize methyl methacrylate. It begins with the initial conversion of acetone to acetone cyanohydrin:
(CH3)2CO + HCN → (CH3)2C(OH)CN
In a subsequent step, the nitrile is hydrolyzed to the unsaturated amide, which is esterified:
(CH3)2C(OH)CN + CH3OH → CH2=(CH3)CCO2CH3 + NH3
The third major use of acetone (about 20%)[13] is synthesizing bisphenol A. Bisphenol A is a component of many polymers such as polycarbonatespolyurethanes, and epoxy resins. The synthesis involves the condensation of acetone with phenol:
(CH3)2CO + 2 C6H5OH → (CH3)2C(C6H4OH)2 + H2O
Many millions of kilograms of acetone are consumed in the production of the solvents methyl isobutyl alcohol and methyl isobutyl ketone. These products arise via an initial aldol condensation to give diacetone alcohol.[14]
2 (CH3)2CO → (CH3)2C(OH)CH2C(O)CH3

Laboratory

In the laboratory, acetone is used as a polaraprotic solvent in a variety of organic reactions, such as SN2 reactions. The use of acetone solvent is critical for the Jones oxidation. It does not form an azeotrope with water (see azeotrope (data)).[38] It is a common solvent for rinsing laboratory glassware because of its low cost and volatility. Despite its common use as a supposed drying agent, it is not effective except by bulk displacement and dilution. Acetone can be cooled with dry ice to −78 °C without freezing; acetone/dry ice baths are commonly used to conduct reactions at low temperatures. Acetone is fluorescent under ultraviolet light, and its vapor can be used as a fluorescent tracer in fluid flow experiments.[39]

Medical and cosmetic uses

Acetone is used in a variety of general medical and cosmetic applications and is also listed as a component in food additives and food packaging and also in nail polish remover. Dermatologists use acetone with alcohol for acne treatments to peel dry skin.
Acetone is commonly used in chemical peeling. Common agents used today for chemical peels are salicylic acid, glycolic acid, 30% salicylic acid in ethanol, and trichloroacetic acid (TCA). Prior to chemexfoliation, the skin is cleaned and excess fat removed in a process called defatting. Acetone, Septisol, or a combination of these agents is commonly used in this process.

Domestic and other niche uses

Acetone is often the primary component in cleaning agents such as nail polish remover. Acetone is a component of superglue remover and easily removes residues from glass and porcelain. Make-up artists use acetone to remove skin adhesive from the netting of wigs and moustaches by immersing the item in an acetone bath, then removing the softened glue residue with a stiff brush.
Acetone is often used for vapor polishing of printing artifacts on 3D-printed models printed with ABS plastic. The technique, called acetone vapor bath smoothing, involves placing the printed part in a sealed chamber containing a small amount of acetone, and heating to around 80 degrees Celsius for 10 minutes. This creates a vapor of acetone in the container. The acetone condenses evenly all over the part, causing the surface to soften and liquefy. Surface tension then smooths the semi-liquid plastic. When the part is removed from the chamber, the acetone component evaporates leaving a glassy-smooth part free of striation, patterning, and visible layer edges, common features in untreated 3D printed parts.
Low-grade acetone is also commonly used in academic laboratory settings as a glassware rinsing agent for removing residue and solids before a final wash.

PRICE

$255.75/KG OR $116.25/IB


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ALUMINIUM OXIDE[Al2O3]

Listing description
Puriss.,.98% Al2O3 basis
Synonym: Alumina
CAS Number 1344-28-1
Linear formular Al2O3
Molecular weight 101.96
EC Number 215-691-6
MDL number MFCD00003424
pubChem substance ID 329749286
eCl@ss 38120402

Properties

Related Categories
More...
InChI Key  
TWNQGVIAIRXVLR-UHFFFAOYSA-N
grade  
puriss.
assay  
≥98% Al2O3 basis
impurities  
≤0.005% heavy metals (as Pb)

≤0.2% alkalis (as Na2O)
loss  
≤0.5% loss on ignition, 1000 °C, 2 h
mp  
2040 °C(lit.)

Aluminaalso called aluminum oxide, synthetically produced aluminum oxide, Al2O3, a white or nearly colourless crystalline substance that is used as a starting material for the smelting of aluminum metal.
Detailed description
It also serves as the raw material for a broad range of advanced ceramic products and as an active agent in chemical processing.

PRICE
$84.82/KG OR $38.55/IB

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Saturday, 14 October 2017

HARMINE OR TELEPATHINE

Listing description
Harmine
98%
Synonym: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
·         CAS Number 442-51-3

·         Empirical Formula (Hill Notation) C13H12N2O

·         Molecular Weight 212.25
·          Beilstein Registry Number 178813

·          EC Number 207-131-4

·          MDL number MFCD00004958
·          PubChem Substance ID 24857229

Properties

Related Categories
InChI Key  
BXNJHAXVSOCGBA-UHFFFAOYSA-N
assay  
98%
mp  
262-264 °C(lit.)
Gene Information  
human ... CDC2(983), CYP2D6(1565)

Description

Biochem/physiol Actions

Central nervous system stimulant.
Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs)[2].

General description

The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied[

Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. It occurs in a number of different plants, most notably the Middle Eastern plant harmal or Syrian rue (Peganum harmala) and the South American vine Banisteriopsis caapi (also known as "yage" or "ayahuasca").
Detailed description
 Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a RIMA. Harmine selectively binds to MAO-A but does not inhibit the variant MAO-B.

Uses

Monoamines include neurotransmitters (serotonin, dopamine), hormones (melatonin, epinephrine, norepinephrine) and psychedelic drugs (psilocybin, DMT and mescaline). By slowing the breakdown of neurotransmitters, monoamine oxidase inhibitors (MAOIs) can help to replenish the body's supply of these chemicals, and many MAOIs are used as antidepressants. Harmine has not been the subject of much clinical research in the treatment of depression, which could be due in part to its restricted legal status in many countries, as well as the existence of synthetic MAOIs with fewer side effects.
P. harmala and B. caapi are both traditionally used for their psychoactive effects. B. caapi has a tradition of use in conjunction with plants containing the drug DMT. Traditionally, B. caapi is consumed as a drink, with or without the DMT-bearing plants (see Ayahuasca). Ordinarily, DMT is not active when taken orally, but users report very different effects when MAOIs are present in such beverages. Harmine and substances containing it have been used in conjunction with many other drugs by modern experimenters. Many hallucinogens appear to exhibit increased potency when used in this way.
Harmine is also a useful fluorescent pH indicator. As the pH of its local environment increases, the fluorescence emission of harmine decreases.
With the radioisotope carbon-11 harmine is used in positron emission tomography neuroimaging to examine its binding to MAO-A.[7]
Harmine found in root secretions of Oxalis tuberosa has been found to have insecticidal properties.[8]
Harmine has been found to increase EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.

Anticancer

"Harmine showed cytotoxicity against HL60 and K562 cell lines. This could explain the cytotoxic effect of P. harmala on these cells."

Effects on bone and cartilage

"Harmine was shown to promote differentiation of osteoblasts (bone-forming cells), and chondrocytes (cells in the cartilage)."
It was also shown to inhibit osteoclastogenesis (the formation of bone resorbing cells)

Packaging

1 g in glass bottle

PRICE

$87233.81/KG OR $39651.73/IB

For more information:

mobile: +2348039721941

contact person: emeaba uche

e-mail: emeabau@yahoo.com