Listing description
Harmine
98%
Synonym: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
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Empirical Formula
(Hill Notation) C13H12N2O
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Molecular
Weight 212.25
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Beilstein
Registry Number 178813
Properties
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Related Categories
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InChI Key
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BXNJHAXVSOCGBA-UHFFFAOYSA-N
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assay
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98%
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mp
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262-264 °C(lit.)
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Gene Information
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Description
Biochem/physiol
Actions
Central nervous system stimulant.
Bottomless glass bottle. Contents are inside
inserted fused cone.
Application
Harmine was used as a donor in the fluorescence
resonance energy transfer (FRET) study between harmine and silver nanoparticles
(AgNPs)[2].
General
description
The combination index (CI, serves as a quantitative
indicator of pharmacological interactions) for harmaline/harmine and methylene
blue/harmine was studied[
Harmine, also known as telepathine,
is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. It occurs in a number of
different plants, most notably the Middle Eastern plant harmal or Syrian rue (Peganum harmala)
and the South American vine Banisteriopsis caapi (also known as "yage" or
"ayahuasca").
Detailed description
Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a RIMA.
Harmine selectively binds to MAO-A but does not inhibit the variant MAO-B.
Uses
Monoamines include neurotransmitters (serotonin, dopamine), hormones (melatonin, epinephrine, norepinephrine) and psychedelic drugs (psilocybin, DMT and mescaline). By slowing the
breakdown of neurotransmitters, monoamine oxidase
inhibitors (MAOIs) can help to replenish the body's supply of these
chemicals, and many MAOIs are used as antidepressants. Harmine has not
been the subject of much clinical research in the treatment of depression,
which could be due in part to its restricted legal status in many countries, as
well as the existence of synthetic MAOIs with fewer side effects.
P. harmala and B. caapi are both traditionally used for their psychoactive effects. B. caapi has a tradition of use in conjunction with
plants containing the drug DMT. Traditionally, B. caapi is consumed as a drink, with or
without the DMT-bearing plants (see Ayahuasca). Ordinarily, DMT is not active when
taken orally, but users report very different effects when MAOIs are present in
such beverages. Harmine and substances containing it have been used in
conjunction with many other drugs by modern experimenters. Many hallucinogens appear to exhibit
increased potency when used in this way.
Harmine is also a useful fluorescent pH indicator.
As the pH of its local environment increases, the fluorescence emission of
harmine decreases.
With the radioisotope carbon-11 harmine is used in positron emission
tomography neuroimaging to examine its binding to MAO-A.[7]
Harmine found in root
secretions of Oxalis tuberosa has been found to
have insecticidal properties.[8]
Harmine has been found to increase EAAT2 glutamate pump
expression in central nervous system, therefore reducing glutamate toxicity.
Anticancer
"Harmine showed cytotoxicity against HL60 and K562 cell lines. This
could explain the cytotoxic effect of P. harmala on these
cells."
Effects on bone and cartilage
"Harmine was shown to promote differentiation
of osteoblasts (bone-forming cells), and chondrocytes
(cells in the cartilage)."
It was also shown to inhibit osteoclastogenesis (the
formation of bone resorbing cells)
Packaging
1 g in glass bottle
PRICE
$87233.81/KG OR $39651.73/IB
For more information:
mobile: +2348039721941
contact person: emeaba uche
e-mail: emeabau@yahoo.com
