analytical standard
Synonym: Acid Red 18, New Coccine, Ponceau 4 R
·
Empirical Formula
(Hill Notation) C20H11N2Na3O10S3
·
Molecular
Weight 604.47
·
Beilstein
Registry Number 4122340
·
Colour Index
Number 16255
·
E
Number E124
Properties
|
Related Categories
|
Additional Standards, All Alphabetically Sorted, All alphabetical sorted, Analytical Standards,Analytical/Chromatography,
More...
|
|
grade
|
analytical standard
|
|
InChI Key
|
SWGJCIMEBVHMTA-ZRUFZDNISA-K
|
|
assay
|
≥99.0% (HPLC)
|
|
form
|
neat
|
|
application(s)
|
HPLC: suitable
|
|
|
gas chromatography (GC): suitable
|
|
format
|
neat
|
Application
Ponceau 4R was used in the determination of contents
of several additives in different non-alcoholic beverages using HPLC. It
was used in understanding the genotoxicity of colorants.[2] It was also
used in preparing a falsified drink in the analysis of methanol-ethanol mixture
using biosensors amperometric system.[3]
Refer to the product′s Certificate of Analysis for
more information on a suitable instrument technique. Contact Technical Service
for further support.
Ponceau 4R (known by more
than 100 synonyms,[1]:460–461 including as C.I.
16255,[2] Cochineal Red A,[2] C.I. Acid Red 18,[2]Brilliant
Scarlet 3R,[2] Brilliant Scarlet 4R,[2] New Coccine,[1]:460 is a synthetic colourant that
may be used as a food colouring. It is denoted
by E Number E124.[2] Its chemical name is 1-(4-sulpho-1-napthylazo)- 2-napthol-
6,8-disulphonic acid, trisodium salt. Ponceau (French for "poppy-coloured")
is the generic name for a family of azo dyes.
Detailed
description
Ponceau 4R is a strawberry red azo dye which
can be used in a variety of food products, and is usually synthesized from aromatic hydrocarbons; it is stable to light, heat, and acid but fades in the
presence of ascorbic acid.[1]:460
Health effects
There is no evidence of carcinogenicity,
genotoxicity, neurotoxicity, or reproductive and developmental toxicity at the
permitted dietary exposures; the European acceptable daily intake (ADI) is
0.7 mg/kg and the WHO/FAO ADI is 4 mg/kg.[1]:460
The production process may result in unsulphonated aromatic amines present in
concentrations of up to 100 mg/kg which may be linked to cancer. The lake pigment form of the colour
additive can also increase the intake of aluminium beyond
the tolerable weekly intake (TWI) of 1 mg/kg/week. Therefore, the limit
for aluminium may be adjusted to accommodate for this.[3]
Possible cause of hyperactivity
Since the 1970s and the well-publicized advocacy of Benjamin Feingold, there has been
public concern that food colourings may cause ADHD-like behavior in children.[4] These concerns have
led the FDA and other food safety authorities to regularly review the
scientific literature, and led the UK FSA to commission a study by researchers
at Southampton University of the effect of a mixture of six food dyes (Tartrazine, Allura Red AC, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow and Carmoisine (dubbed
the "Southampton 6")) and sodium benzoate (a preservative) on
children in the general population, who consumed them in beverages; the study
published in 2007.[4][5] The study found
"a possible link between the consumption of these artificial colours and a
sodium benzoate preservative and increased hyperactivity" in the children;[4][5] the advisory
committee to the FSA that evaluated the study also determined that because of
study limitations, the results could not be extrapolated to the general
population, and further testing was recommended".[4]
The European regulatory community, with a stronger
emphasis on the precautionary principle, required labelling and temporarily reduced the acceptable daily intake (ADI) for the food
colourings; the UK FSA called for voluntary withdrawal of the colourings by
food manufacturers.[4][5] However, in 2009 the
EFSA re-evaluated the data at hand and determined that "the available
scientific evidence does not substantiate a link between the colour additives
and behavioural effects".[3][4]
The US FDA did not make changes following the
publication of the Southampton study, but following a citizen petition filed by
the Center for Science
in the Public Interest in 2008, requesting
the FDA ban several food additives, the FDA commenced a review of the available
evidence, and still made no changes.[4]
There is no evidence to support broad claims that
food colouring causes food intolerance and ADHD-like behaviour in children.[6]:452 It is possible that
certain food colouring may act as a trigger in those who are genetically
predisposed, but the evidence is weak.
Packaging
Bottomless glass bottle. Contents are inside
inserted fused cone.
PRICE
$5523154.27/KG
OR $2510524.66/IB
For more information:
mobile: +2348039721941
contact person: emeaba uche
e-mail: emeabau@yahoo.com
No comments:
Post a Comment