CHELERYTHRINE CHLORIDE

·         CAS Number 3895-92-9

·         Empirical Formula (Hill Notation) C₂₁H₁₈ClNO₄

·         Molecular Weight 383.82

·          EC Number 223-444-9

·          MDL number MFCD00060717

·          PubChem Substance ID 24278305

Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC₅₀=0.66 μM), and an independent activator of MAPK pathways

Detailed description

 The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC₅₀ = 1.5 μM. When used in combination with cisplatin (sc-200896) inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.

PRICE

$100.22/KG OR $45.55/IB

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