GALACTITOL(SUGAR ALCOHOL) [C6H14O6]

United States Pharmacopeia (USP) Reference Standard

Synonym: Dulcite, Dulcitol, Galactitol

·         CAS Number 608-66-2

·         Empirical Formula (Hill Notation) C₆H₁₄O₆

·         Molecular Weight 182.17

·          Beilstein Registry Number 1721903

·          MDL number MFCD00064288

·          PubChem Substance ID 329749924

Properties

Related Categories	Analytical Standards, Analytical/Chromatography,Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards G - H More...
InChI Key	FBPFZTCFMRRESA-GUCUJZIJSA-N

Galactitol (dulcitol) is a sugar alcohol, the reduction product of galactose. In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens of the eye leading to cataracts.

Detailed description

Galactitol is produced from galactose in a reaction catalyzed by aldose reductase. Galactose itself comes from the metabolism of the disaccharide lactose into glucose and galactose.

The other common galactose metabolism defect is a defect in galactose-1-phosphate uridylyltransferase, an autosomal recessive disorder, which also causes a buildup of galactitol as a result of increased concentrations of galactose-1-phosphate and galactose. The toxicity associated with galactose-1-phosphate uridylyltransferase deficiency is associated with symptoms of hepatosplenomegaly and mental retardation in addition to the cataracts caused by galactitol buildup.

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$1037253.88/KG OR $471479.03/IB

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