from Tinospora sagittata,
≥95% (HPLC)
Synonym: 7,8,13,13α-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium,
Neprotin, Yatrorizine
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Empirical Formula
(Hill Notation) C20H20NO4
·
Molecular
Weight 338.38
Properties
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Related Categories
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biological source
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from Tinospora sagittata
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assay
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≥95% (HPLC)
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storage temp.
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2-8°C
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Jatrorrhizine is a protoberberine alkaloid isolated from Enantia
chlorantha (Annonaceae) and other species.[1] Synonyms that may be encountered include jateorrhizine,
neprotin, jatrochizine, jatrorhizine, or yatrorizine.
DETAILED
DESACRIPTION
It has been reported to have antiinflammatory
effect,[2] and to improve blood flow and
mitotic activity in thioacetamide-traumatized rat livers.[3] It was found
to have antimicrobial[4] and antifungal[5] activity. It
binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B)[6] It interferes
with multidrug resistance by cancer cells in vitro when exposed to
a chemotherapeutic agent.[7] Large doses
(50–100 mg/kg) reduced blood sugar levels in mice by increasing
aerobic glycolysis.
Derivatives of jatrorrhizine (notably 3-alkoxy
derivatives, and specifically 3-octyloxy 8-alkyljatrorrhizine derivatives such
as 3-octyloxy 8-butyljatrorrhizine) have been synthesized and found to have
much stronger antimicrobial effects.
Packaging
10 mg in glass bottle
50 mg in poly bottle
PRICE
$30020.77/KG OR $13645.80/IB
For more information:
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